Advances in CAR-T Cell Therapy

Various barriers restrict the efficacy and/or prevent the widespread use of CAR-T cell therapies in these patients as well as in those with other diseases, particularly solid tumors. The evolution of CAR designs beyond conventional structures will be necessary to address these limitations and expand the use of CAR-T cells to a wider range of diseases. In this presentation, we discuss the progress in the development of innovative designs for new CAR-T cell products to increase and expand the clinical benefits of these treatments for patients with various cancers, and we explore the potential of CAR-T cell therapies in addressing diseases beyond cancer.